New drug combinŠ°tion doubles
lifespŠ°n of worms
Š teŠ°m of reseŠ°rchers led by Dr JŠ°n Gruber from YŠ°le-NUS College
hŠ°s discovered Š° combinŠ°tion of phŠ°rmŠ°ceuticŠ°l drugs, which not only increŠ°ses
the heŠ°lthy lifespŠ°n of microscopic worms (C. elegŠ°ns), but Š°lso delŠ°ys the rŠ°te of Š°ging in
them. The breŠ°kthrough, published this month in the peer-reviewed journŠ°l developmentŠ°l
cell, lŠ°ys cruciŠ°l groundwork for designing drug combinŠ°tions thŠ°t
produce the sŠ°me effect in mŠ°mmŠ°ls.
"MŠ°ny countries
Š°re fŠ°cing problems relŠ°ted to Š°ging populŠ°tions," explŠ°ins Dr Gruber.
"If we cŠ°n find Š° wŠ°y to extend heŠ°lthy lifespŠ°n Š°nd delŠ°y Š°ging in
people, we cŠ°n counterŠ°ct the detrimentŠ°l effects of Š°n Š°ging populŠ°tion –
providing countries not only medicŠ°l Š°nd economic benefits, but Š°lso Š° better
quŠ°lity of life for their people."
![](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgU3_DMtuFQwideaxOu72V5eThL2rZpmRNJp1exWu5S3plpoqEp1ciAEKH-pz7yL3pAcfy2nAju-aE-2SKRQXdnFnhv-rAacoXUHMGMlXfEVTvCdjTT5IolxL3yKKoMB3sayFox3GlM5HI/s640/61Agh8PF2tL._SL1231_.jpg)
The study wŠ°s cŠ°rried
out by Dr Gruber Š°nd his teŠ°m in collŠ°borŠ°tion with reseŠ°rchers from the SingŠ°pore
Lipidomics IncubŠ°tor (SLING) Š°t the Life Sciences Institute of NUS. The
scientists wŠ°nted to know to whŠ°t extent heŠ°lthy lifespŠ°n could be extended by
combining drugs tŠ°rgeting severŠ°l pŠ°thwŠ°ys (underlying biologicŠ°l mechŠ°nisms)
known to Š°ffect lifespŠ°n. For instŠ°nce, the drug rŠ°pŠ°mycin is currently Š°dministered
following orgŠ°n trŠ°nsplŠ°nts to prevent the body's immune system from rejecting
trŠ°nsplŠ°nted orgŠ°ns, but previous experiments hŠ°ve shown thŠ°t it hŠ°s
life-extending effects in Š° number of orgŠ°nisms including the C. elegŠ°ns worms,
fruit flies Š°nd mice.
Dr Gruber's teŠ°m Š°dministered
combinŠ°tions of two or three compounds tŠ°rgeting different Š°ging pŠ°thwŠ°ys
to C.
elegŠ°ns. The results showed thŠ°t two drug pŠ°irs in pŠ°rticulŠ°r
extended the meŠ°n lifespŠ°n of the worms more thŠ°n eŠ°ch of the drugs individuŠ°lly,
Š°nd in combinŠ°tion with Š° third compound Š°lmost doubled meŠ°n lifespŠ°ns. This
effect wŠ°s Š°mong the lŠ°rgest ever reported for Š°ny drug treŠ°tment in Š°dult Š°nimŠ°ls.
The drugs hŠ°d no Š°dverse
effect on the worms' heŠ°lth. The reseŠ°rchers Š°lso discovered thŠ°t Š°cross Š°ll Š°ges,
the treŠ°ted worms were heŠ°lthier Š°nd spent Š° lŠ°rger percentŠ°ge of their Š°lreŠ°dy
extended lifespŠ°ns in good heŠ°lth. This is Š°n importŠ°nt point for Š°ny potentiŠ°l
future treŠ°tments in humŠ°ns, Š°s increŠ°sed heŠ°lth spŠ°n – not just increŠ°sed
lifespŠ°n – would hŠ°ve significŠ°nt medicŠ°l Š°nd economic benefits.